Session 9: Keynote Lecture 2

Chairs: Laura Humphrys & Marcel Bermúdez

Denise Wootten (Monash Institute of Pharmaceutical Sciences, Melbourne, Victoria, Australia)

Structural and mechanistic insights into class B1 GPCR activation, signalling and allostery

Brief reports from Industry 2

Chairs: Katarina Nemec & Miriam Scarpa

Sophie Bradley & Chris De Graaf (Sosei Heptares, Cambridge, UK)

From structure to clinic: taking muscarinic drug discovery to the next level

Session 10: Spotlight on ECI researchers

Chairs: Laura Humphrys & Theresa Noonan

Xiaojing Cong (Institut de Génomique Fonctionnelle, Montpellier, France)

Machine learning of sequence-function relationships of olfactory receptors

Tianyi Ding (Queen’s University Belfast, Northern Ireland)

Ligand binding site mapping at GPCR-Lipid Interface

Khaled Abd-Elrahman (University of Ottawa, Canada)

A positive allosteric modulator of M1 Acetylcholine receptors improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice

Susanne Prokop (Institute of Experimental Medicine, Budapest, Hungary)

PharmacoSTORM: a novel approach for the nanoscale imaging of drug binding sites

Nipuna Weerasinghe (University of Arizona, USA)

The Modulation of Conformational Energetics of GPCR Activation by Water

Lina Verbakel (Fribourg, Switzerland and KU Leuven, Belgium)

Prothoracicostatic Activity of the Ecdysis-Regulating Neuropeptide Crustacean Cardioactive Peptide (CCAP) in the Desert Locust

Infant Sagayaraj Ravhe (Indian Institute of Technology Madras, India)

Evolutionary history of histamine receptors: Early vertebrate origin and expansion of the H3 - H4 subtypes

Flash Poster Talks 3

Pre-recorded 3 minute talks selected from submitted abstracts

Chairs: Miriam Scarpa & Sarah Hesse

3.1 Eloise Euston (Institute of Molecular, Cell and Systems Biology, University of Glasgow, UK)

Pharmacological Evaluation of Novel FFA4 Compounds

3.2 Marija Carapic (Faculty of Pharmacy, University of Belgrade, Serbia)

Investigation of retention characteristics and an unknown degradant of ziprasidone, antipsychotic with unique profile binding for GPCRs receptor

3.4 Yuanyuan Ma (University of Copenhagen, Denmark)

Quantitative fluorescence imaging of ligand binding events on the beta-1 adrenergic receptor

3.5 Paulina Dragan (University of Warsaw, Poland)

Functional aspects of helix H8 in signal transduction of chemotactic receptors

3.6 Vidicha Chunilal (William Harvey Research Institute, UK)

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling

3.7 Alba Paz (University of Santiago de Compostela, Spain)

Intracellular signaling components of fractalkine receptor CX3CR1 and its rare genetic variant CX3CR1-Ala55Thr

3.8 Nikolaj Brinkenfeldt (University of Copenhagen, Denmark)

Dose response curves established based on single cell cAMP measurements by quantitative fluorescence microscopy

3.9 Milica Radan (Faculty of Pharmacy, University of Belgrade, Serbia)

Drug design strategies in discovery of new chemotypes of dual 5-HT2A/D2-R antagonists

3.10 Eszter Szanti-Pinter (Czech Academy of Sciences, Czech Republic)

Allosteric Modulation of Muscarinic Acetylcholine Receptors by Neurosteroids and Steroid Hormones

Poster presentations

Opportunity to network and visit poster presenters in Wonder

Lunch

Session 11: Spatiotemporal dimensions of signaling

Chairs: Leire Borrega & Laura Humphrys

Andreas Bock (Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Germany)

Optical mapping reveals spatiotemporal GPCR signaling at the nanoscale

Bianca Plouffe (Queen’s University Belfast, Northern Ireland)

The viral-encoded US28 receptor contributing to glioblastoma development constitutively activates Gq from early endosomes

Shannon O'Brien (University of Birmingham, England)

Investigating GPCR signalling in adipocytes

Session 12: GPCRs in health and disease

Chairs: Miriam Scarpa & Katarina Nemec

Kathleen M. Caron (University of North Carolina at Chapel Hill, USA)

Illuminating Orphan GPCRs in Cardiovascular Development and Function

Karina A. Peña (University of Pittsburgh, USA)

Location Bias in cAMP and PTHR Biology

Mirja Harms (Ulm University Medical Center, Germany)

The CXCR4 inhibitor EPI-X4 – from discovery to drug design

Mercedes Alfonso-Prieto (Forschungszentrum Jülich, Germany)

Structure-function effects of a disease-linked variant of the oxytocin receptor

Claudia Stäubert (University Leipzig, Medical Faculty, Germany)

Hydroxycarboxylic acid receptor 3 and GPR84 – two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells

Conference Close & Prizes